What Strain of Marijuana is Good for Anxiety?

Know the most potent marijuana strains that are good for anxiety and stress and get tips on finding the right cannabis strain for you.

Anxiety disorders affect over 40 million adults in the United States alone, leaving many feeling overwhelmed and constantly on edge. Even basic tasks can become mountains to climb when your mind is flooded with worry, fear, and unease.

While there’s no single solution that works for everyone, many people have found relief from anxiety with cannabis. This unexpected ally offers a path toward managing those everyday struggles. 

This guide dives into some cannabis strains that might be helpful for your specific anxiety symptoms.

How Marijuana Can Help with Anxiety

Cannabis interacts with the body’s endocannabinoid system (ECS), which regulates functions like stress management. This interaction may mimic anti-anxiety medications by influencing GABA, a stress-regulating neurotransmitter [1]. 

Studies show CBD, a non-psychoactive compound in cannabis, can modulate GABA activity. Additionally, cannabis may lower cortisol, a stress hormone. Research also suggests CBD strains may improve sleep, further reducing anxiety. 

While more studies are needed, cannabis, particularly CBD-dominant strains, could be a natural remedy for anxiety. However, consult a healthcare professional before use as individual responses vary.

Best Marijuana Strains for Anxiety

If you’re exploring cannabis as a potential anxiety aid, certain strains are better suited than others. Here are some of the top-recommended varieties:

Sour Tsunami

Renowned for its high CBD content and low THC levels, Sour Tsunami is a hybrid strain that offers potent anxiety relief without the intense psychoactive effects associated with THC. 

Its terpene profile, rich in myrcene and caryophyllene, is believed to contribute to its calming properties.

OG Kush

A classic Indica-dominant strain, OG Kush is celebrated for its relaxing, sedative effects that can help quiet racing thoughts and ease physical tension. 

With its earthy, musty aroma and high myrcene content, this strain is a popular choice for those seeking a serene, anxiety-free state.

Jack Herer

Named after the renowned cannabis activist, Jack Herer is a Sativa-dominant hybrid known for its uplifting, mood-boosting qualities. Its unique terpene profile, featuring pinene and caryophyllene, may help alleviate anxiety while promoting focus and clarity.

Wedding Cheesecake

As its name suggests, Wedding Cheesecake is a delightful hybrid strain with a sweet, creamy aroma. Its balanced THC and CBD levels make it a versatile option for managing anxiety, while its myrcene and limonene terpenes contribute to its relaxing, uplifting effects.


ACDC is a high-CBD strain that offers measurable relief from anxiety and inflammation without the psychoactive impact of THC. Its dominant terpenes, myrcene and caryophyllene, are renowned for their anxiety-relieving properties, making ACDC a popular choice among medical cannabis users.

Blue Dream

A well-balanced hybrid, Blue Dream is celebrated for its ability to induce a sense of calm and relaxation while maintaining mental clarity. Its unique terpene profile, featuring myrcene, pinene, and caryophyllene, contributes to its anxiety-reducing properties.

Granddaddy Purple

This indica-dominant strain is a true classic, known for its profoundly relaxing abilities that can help soothe tense muscles and quiet racing thoughts. 

With its high myrcene and linalool content, Granddaddy Purple is an excellent choice for managing evening-time stress or panic attacks.

Apple Fritter

With its delightful fruity aroma and well-balanced effects, Apple Fritter is a hybrid strain that can help alleviate anxiety while promoting a sense of euphoria. Its limonene and caryophyllene terpenes contribute to its uplifting and calming properties.

Skywalker Kush

An indica-dominant strain with a potent sedative effect, Skywalker Kush is renowned for its ability to induce a deep sense of relaxation and tranquility. Its high myrcene content is believed to contribute to its anxiety-relieving properties, making it an excellent choice for those seeking respite from stress and tension.

Ice Cream Cake

With its sweet, creamy aroma and balanced effects, Ice Cream Cake is a hybrid strain that can help alleviate anxiety while promoting a sense of euphoria. Its unique terpene profile, featuring caryophyllene and limonene, contributes to its calming and uplifting properties.

While these strains are generally well-regarded for their anxiety-relieving potential, it’s essential to remember that individual responses can vary. Consulting with a healthcare professional or a knowledgeable budtender can help you find the strain that best suits your specific needs.

How to Relieve Anxiety With Medical Marijuana Strains

Once you’ve identified a suitable cannabis strain for your anxiety, it’s crucial to understand the various consumption methods available and how they can impact your experience. Here are some popular options:


Smoking or vaporizing cannabis allows for rapid onset, with effects typically felt within minutes. This method is ideal for those seeking quick relief from acute anxiety or panic attacks. However, the effects are relatively short-lived, lasting 2-3 hours.

Sublingual Administration

Tinctures and sublingual sprays offer a discreet and smoke-free alternative. By absorbing the cannabinoids through the mucous membranes in the mouth, the effects can be felt within 15-30 minutes and last for several hours.


While the onset time for THC edibles can be slower (up to 2 hours), the effects tend to be more potent and long-lasting, often persisting for 6-8 hours or more. This method is well-suited for those seeking sustained anxiety relief throughout the day or night.


Topical cannabis products, such as lotions, balms, and transdermal patches, can be applied directly to the skin and may help alleviate localized anxiety-related symptoms like muscle tension or inflammation. However, their effects are primarily localized and non-psychoactive.


For some individuals, consuming smaller doses of cannabis throughout the day can provide consistent, low-level anxiety relief without inducing intense psychoactive effects. This approach requires careful dosage monitoring and may take some trial and error to find the optimal balance.

Remember, start low and go slow when trying a 

new strain or consumption method, as individual responses can vary significantly. Additionally, be mindful of potential side effects and consult a healthcare professional, especially if you’re taking other medications.

Indica vs. Sativa: Which is Better for Anxiety?

Indica strains, known for relaxation, may help with anxiety symptoms like tension and trouble sleeping. 

Sativa strains are described as energizing; while they alleviate anxiety for some, they can worsen anxiety for some users. Most strains are hybrids, combining indica and sativa effects. 

Beyond indica/sativa, factors like terpenes, cannabinoid content, and your individual body chemistry play a big role. Indica-dominant hybrids or strains rich in CBD might be better for anxiety, but finding the right fit requires trying different options.

The Role of CBD and THC in Managing Anxiety

The cannabis plant contains two key compounds, CBD and THC, which affect anxiety differently. CBD, non-psychoactive, is known for its potential to relieve anxiety by interacting with the body’s systems like serotonin and GABA. 

THC, psychoactive, can help some with anxiety at low doses but may worsen symptoms or trigger panic at higher doses, especially for those prone to anxiety.

Experts often recommend marijuana strains with higher CBD-to-THC ratios or CBD-dominant strains for anxiety management. These strains offer the potential benefits of CBD without inducing paranoia or anxiety. 

However, individual responses vary; some may find a balanced CBD-THC ratio more effective. It’s essential to start with low doses, monitor reactions, and consult a healthcare professional, especially when taking other medications.

How to Choose the Right Marijuana Strain for Your Anxiety

With the vast array of cannabis strains available, selecting the right one for your anxiety can be a daunting task. Here are some key factors to consider:

  1. Cannabinoid Profile: Look for strains with a higher CBD-to-THC ratio or CBD-dominant varieties, as these are generally better tolerated for anxiety relief. However, some individuals may find that a balanced ratio works best for them.
  2. Terpene Profile: Terpenes, the aromatic compounds found in cannabis, can influence the plant’s effects. Strains rich in terpenes like myrcene, caryophyllene, and limonene are often recommended for their potential anxiety-relieving properties.
  3. Indica vs. Sativa: While the indica vs. sativa distinction is not a definitive indicator of effects, many individuals find that Indica-dominant or hybrid strains are better suited for anxiety relief due to their more relaxing sedative properties.
  4. Personal Preferences: Consider your desired effects—do you prefer a more physically relaxing experience or a more uplifting, cerebral high? Also, consider your tolerance levels and any potential interactions with medications you’re currently taking.
  5. Reputable Sources: Purchase your cannabis from reputable sources, such as licensed dispensaries or trusted online retailers, to ensure you’re getting a high-quality, accurately labeled product.

Potential Side Effects When Using Marijuana for Your Anxiety

While cannabis can be an effective natural remedy for anxiety, it’s important to be aware of potential side effects, especially when using strains with higher THC levels or consuming larger doses.

Common side effects of marijuana use may include:

  • Dry mouth (cottonmouth)
  • Increased appetite (munchies)
  • Bloodshot eyes
  • Dizziness or lightheadedness
  • Impaired coordination and reaction time
  • Short-term memory impairment
  • Anxiety or paranoia (particularly with high THC strains)

When to Talk to a Doctor

While cannabis can be a valuable tool for managing anxiety, it’s important to recognize when professional medical assistance is necessary. Here are some situations where you should consider consulting with a healthcare professional:

  1. Severe/persistent anxiety impacting daily life – seek medical help for diagnosis and treatment plan.
  2. Underlying medical conditions – discuss cannabis use with doctor to avoid conflicts with existing treatment.
  3. Taking prescription medications – consult doctor/pharmacist before using cannabis to avoid interactions.
  4. Pregnant/breastfeeding – avoid cannabis due to potential risks for fetus/newborn.
  5. History of mental health issues – consult a mental health professional before using cannabis to avoid worsening symptoms.
  6. No improvement in anxiety – consult a healthcare professional to explore other options.


Here, wr answers a few frequently asked questions about which marijuana strains are good for anxiety.

What Strain Makes You Feel Motivated?

Sativa-dominant strains, such as Jack Herer, Green Crack, and Durban Poison, are often associated with feelings of increased energy, focus, and motivation, making them popular choices for daytime use.

What Strain Helps with Relaxation?

Indica-dominant strains like Northern Lights, Granddaddy Purple, and Afghan Kush are renowned for their deeply relaxing, sedative effects, making them ideal for unwinding and relieving stress and tension.

What Is the Best Weed for Nausea and Anxiety?

Strains with a balanced CBD-to-THC ratio, such as Harlequin, Cannatonic, and ACDC, are often recommended for managing both nausea and anxiety, as they can provide relief without inducing intense psychoactive effects.

Why Does Sativa Calm Me Down?

While sativas are generally associated with more energizing and uplifting effects, some individuals may experience a calming or relaxing effect from certain sativa strains. 

This can be attributed to factors like individual biochemistry, terpene profiles, and the specific strain’s cannabinoid content.

What are the best pre rolls for anxiety?

Some popular pre-roll options for anxiety relief include CBD-dominant strains like Harlequin, ACDC, and Cannatonic, as well as balanced hybrid strains like Canna-Tsu and Remedy.

What Is the Best Strain for Anxiety and ADHD?

Strains with a balanced ratio of CBD and THC, such as Sour Tsunami, Canna-Tsu, and Harlequin, are often recommended for individuals dealing with both anxiety and ADHD. These strains can provide a calming effect while maintaining focus and clarity, potentially alleviating symptoms of both conditions.

What Strain Helps with Relaxation?

Indica-dominant strains like Granddaddy Purple, Northern Lights, and Afghan Kush are renowned for their deeply relaxing sedative effects, making them excellent choices for unwinding after a long day or relieving physical tension and stress.

Which is better, indica or sativa?

There is no definitive answer, as individual responses can vary greatly. 

However, many individuals find that Indica-dominant or hybrid strains with higher CBD levels are better suited for managing anxiety due to their more relaxing sedative effects. At the same time, sativas are often associated with more energizing and uplifting sensations.

What Strain Makes You Feel Motivated?

Sativa-dominant strains, such as Jack Herer, Green Crack, and Durban Poison, are often associated with increased energy, focus, and motivation, making them popular choices for daytime use or when you need a burst of creativity and productivity.

Final Words

Finding the right cannabis strain for anxiety relief can be a personal journey. While this guide highlights some popular options, remember everyone reacts differently. Start low, listen to your body, and gradually increase the dosage until you find relief. 

Consult budtenders, healthcare providers, or therapists familiar with cannabis for personalized advice. Cannabis should complement, not replace, professional medical care. 

If anxiety persists, seek professional help to explore other options. 


  1. Yarar E. Role and Function of Endocannabinoid System in Major Depressive Disease. Med Cannabis Cannabinoids. 2020 Dec 11;4(1):1-12. doi: 10.1159/000511979. PMID: 34676346; PMCID: PMC8525214.